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Table 2 Comparison of RAAS with normotensive OSA, healthy population and primary aldosteronism, matched for age and gender

From: Hypertension in obstructive sleep apnea: the hidden role of renin–angiotensin–aldosterone system dysregulation

Comparisons

RAAS parameters, median (IQR)

PAC, ng/dL

p

PRC, μIU/mL

p

ARR, ng/dL:μIU/mL

p

Matched pair 1

      

 Hypertensive OSA, n = 31

9.69 (6.63, 11.78)

 < 0.001

14.55 (10.17, 35.75)

0.584

0.485 (0.358, 0.860)

0.089

 Normotensive OSA, n = 31

6.16 (4.20, 8.09)

15.0 (9.14, 25.9)

0.383 (0.231, 0.722)

Matched pair 2

      

 Hypertensive OSA, n = 105

9.17 (6.54, 11.55)

0.008

15.47 (8.12, 27.86)

0.004

0.53 (0.34, 0.98)

 < 0.001

 Healthy, n = 105

7.23 (5.63, 10.26)

23.46 (14.1, 32.44)

0.34 (0.22, 0.54)

Matched pair 3

      

 Hypertensive OSA, n = 99

9.0 (6.26, 11.40)

 < 0.001

13.62 (7.18, 23.39)

 < 0.001

0.590 (0.380, 1.030)

 < 0.001

 Primary aldosteronism, n = 99

33.02 (19.80, 61.59)

5.41 (1.64, 12.69)

6.788 (2.357, 15.294)

  1. RAAS: renin–angiotensin–aldosterone system; OSA: obstructive sleep apnea; PAC: plasma aldosterone concentration; PRC: plasma renin concentration; ARR: aldosterone-to-renin ratio
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Tropical Medicine and Health

ISSN: 1349-4147

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