Fig. 2
From: From pox to protection: understanding Monkeypox pathophysiology and immune resilience
Many of the MPXV's proteins interact with infectious agent receptor signaling cascades, controlling the expression of pro-inflammatory genes with the value as nuclear factor kappa B cells (NF-B) and interferon-regulated factor 3 (IRF3). This allows the virus to avoid protecting individuals. MPXV reduces interferon signaling by blocking IFN/binding, IFN/production, and PKR-mediated pathways. It produces antibodies that target inflammatory molecules such as IFN gamma, TNF, IL-18, IL-6, and IL-1 beta. MPXV may avoid infected cells from dying by producing proteins that inhibit apoptotic pathways. It also reduces T-cell and natural killer activation