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Table 1 Diagnostic 2 × 2 tables and parameters of IgG test by ELISA and IIP

From: Exploratory study of antibody titers against SARS-CoV-2 using an indirect immunoperoxidase assay in COVID-19 patients and vaccinated volunteers

IgG ELISA

OD ratio > 1.1

Patients

Controls

Total

Proportion (%)

(95% CI)

Positive

88

0

88

PPV = 100

(95.9–100)

Negative

58

38

96

NPV = 39.6

(29.7–50.1)

Total

146

38

184

Prevalence

 = 79.3

Proportion (%)

(95% CI)

Sn = 60.3

(51.9–68.3)

Sp = 100

(90.7–100)

Accuracy = 68.5

(61.2–75.1)

IIP IgG

titer >  = 80

Patients

Controls

Total

Proportion (%)

(95% CI)

Positive

120

2

122

PPV = 98.4

(94.2–99.8)

Negative

26

36

62

NPV = 58.1

(44.8–70.5)

Total

146

38

184

Prevalence

 = 79.3

Proportion (%)

(95% CI)

Sn = 82.2

(75.0–88.0)

Sp = 94.7

(82.3–99.4)

Accuracy = 84.8

(78.8–89.6)

  1. ELISA enzyme-linked immunosorbent assay, OD optical density, CI confidence interval, PPV positive predictive value, NPV negative predictive value, Sn sensitivity, Sp specificity, IIP indirect immunoperoxidase assay